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Article

Tau filaments from human brain and from in vitro assembly of recombinant protein show cross-beta structure.

Proceedings of the National Academy of Sciences of the United States of America - 22 Jul 2003

Berriman John, Serpell Louise C, Oberg Keith A, Fink Anthony L, Goedert Michel, Crowther R Anthony

Abstract excerpt

Abnormal filaments consisting of hyperphosphorylated microtubule-associated protein tau form in the brains of patients with Alzheimer's disease, Down's syndrome, and various dementing tauopathies. In Alzheimer's disease and Down's syndrome, the filaments have two characteristic morphologies referred to as paired helical and straight filaments, whereas in tauopathies, there is a wider range of morphologies. There...

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Identifiers

PMID: 12853572
DOI: 10.1073/pnas.1530287100
PMCID: PMC166433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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