Article
Cryo-EM structures of cotton wool plaques' amyloid β and of tau filaments in dominantly inherited Alzheimer disease.
Acta neuropathologica - 15 Aug 2024
Hoq Md Rejaul, Fernandez Anllely, Vago Frank S, Hallinan Grace I, Bharath Sakshibeedu R, Li Daoyi, Ozcan Kadir A, Garringer Holly J, Jiang Wen, Vidal Ruben, Ghetti Bernardino
Abstract excerpt
Cotton wool plaques (CWPs) have been described as features of the neuropathologic phenotype of dominantly inherited Alzheimer disease (DIAD) caused by some missense and deletion mutations in the presenilin 1 (PSEN1) gene. CWPs are round, eosinophilic amyloid-β (Aβ) plaques that lack an amyloid core and are recognizable, but not fluorescent, in Thioflavin S (ThS) preparations. Amino-terminally truncated and...
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