Article

Emergence of distinct and heterogeneous strains of amyloid beta as Alzheimer’s disease progresses in Down syndrome

2021-07-31

Abstract excerpt

0. <h4>ABSTRACT</h4> Amyloid beta (Aβ) is thought to play a critical role in the pathogenesis of Alzheimer’s disease (AD). Prion-like Aβ polymorphs, or “strains”, can have varying pathogenicity and may underlie the phenotypic heterogeneity of the disease. In order to develop effective AD therapies, it is critical to identify the strains of Aβ that might arise prior to the onset of clinical symptoms and understand...

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Literature Corpus work: b9d24f56-567a-58a3-adc6-fe2c15d5da7b
DOI: 10.1101/2021.07.30.454527

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