Article

GEM-Finder: dissecting GWAS variants via long-range interacting cis-regulatory elements with differentiation-specific genes

2025-03-03

Abstract excerpt

Interpreting the functional significance of non-coding GWAS variants remains challenging. While co-localizing variants with cell-type specific cis-regulatory elements (CREs) has improved our understanding, many variants remain unassociated. In this study, we propose GEM-Finder (Genomic Element Mapping for Fine Discovery of Promoter-Linked Variants), a novel analytical framework that integrates transcriptomic, epig...

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Literature Corpus work: d75ea9a3-77e5-5009-8e8f-0e0cfed6b7e3
DOI: 10.1101/2025.03.02.25323165

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