Article

Functional enrichments of disease variants across thousands of independent loci in eight diseases

2016-04-11

Abstract excerpt

For most complex traits, known genetic associations only explain a small fraction of the narrow sense heritability prompting intense debate on the genetic basis of complex traits. Joint analysis of all common variants together explains much of this missing heritability and reveals that large numbers of weakly associated loci are enriched in regulatory regions, but fails to identify specific regions or biological p...

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Literature Corpus work: 4558604f-2d4e-52cd-99be-abe618e191bf
DOI: 10.1101/048066

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