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Article

Integrative analysis of 3604 GWAS reveals multiple novel cell type-specific regulatory associations.

Genome biology - 7 Jan 2022

Breeze Charles E, Haugen Eric, Reynolds Alex, Teschendorff Andrew, van Dongen Jenny, Lan Qing, Rothman Nathaniel, Bourque Guillaume, Dunham Ian, Beck Stephan, Stamatoyannopoulos John, Franceschini Nora, Berndt Sonja I

Abstract excerpt

BACKGROUND: Genome-wide association study (GWAS) single nucleotide polymorphisms (SNPs) are known to preferentially co-locate to active regulatory elements in tissues and cell types relevant to disease aetiology. Further characterisation of associated cell type-specific regulation can broaden our understanding of how GWAS signals may contribute to disease risk. RESULTS: To gain insight into potential functional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Regulatory Sequences, Nucleic Acid

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Identifiers

PMID: 34996498
DOI: 10.1186/s13059-021-02560-3
PMCID: PMC8742386

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