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Discover novel disease-associated genes based on regulatory networks of long-range chromatin interactions.

Methods (San Diego, Calif.) - 1 May 2021

Wang Hao, Yang Jiaxin, Zhang Yu, Wang Jianrong

Abstract excerpt

Identifying genes and non-coding genetic variants that are genetically associated with complex diseases and the underlying mechanisms is one of the most important questions in functional genomics. Due to the limited statistical power and the lack of mechanistic modeling, traditional genome-wide association studies (GWAS) is restricted to fully address this question. Based on multi-omics data integration,...

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Chromatin
Chromatin Immunoprecipitation Sequencing
Epigenomics
Gene Regulatory Networks
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33096239
DOI: 10.1016/j.ymeth.2020.10.010
PMCID: PMC8026483

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