Article

Altered IL-6 signalling and risk of tuberculosis disease: a meta-analysis and Mendelian randomisation study

2023-02-08

Abstract excerpt

<h4>Summary</h4> IL-6 responses are ubiquitous in Mycobacterium tuberculosis (Mtb) infections, but their role in determining human tuberculosis (TB) disease risk is unknown. We used single nucleotide polymorphisms (SNPs) in and near the IL-6 receptor (IL6R) gene, focusing on the non-synonymous variant, rs2228145, associated with reduced classical IL-6 signalling, to assess the effect of altered IL-6 activity on TB...

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Literature Corpus work: d73e4bda-ed4f-5f45-8f07-e20d1fd77b4e
DOI: 10.1101/2023.02.07.23285472

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