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Genetic perturbation of IL-6 receptor signaling pathway and risk of multiple respiratory diseases

19 Jun 2024

Abstract excerpt

Dysregulation of inflammation can lead to multiple chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and asthma. Interleukin-6 (IL6) is crucial in regulating the inflammatory cascade, but the causal link between IL6 signaling downregulation and respiratory diseases risk is unclear. This study uses Mendelian randomization to examine the effects of IL6R blockade on respiratory...

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PMID: 38898459
DOI: 10.1186/s12967-024-05366-6

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