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Leveraging genetic data to investigate the effects of interleukin-6 receptor signalling on levels of 40 circulating cytokines.

2021-06-23

Abstract excerpt

Abstract Interleukin 6 (IL-6) is a circulating cytokine that is implicated in a range of inflammatory diseases. However, the broad effects of IL-6 receptor (IL-6R) signalling on other circulating cytokines is not known. Using summary-level data from genome-wide association studies, we leveraged genetic variants that proxy IL-6R signalling in two-sample Mendelian randomization analyses to investigate effects on lev...

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Literature Corpus work
52276ea2-0762-510f-a9de-29bd44785af7
DOI
10.22541/au.162444899.91361799/v1
Open publication

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Leveraging genetic data to investigate the effects of interleukin-6 receptor signalling on levels of 40 circulating cytokines.DOI 10.22541/au.162444899.91361799/v1
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