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A Common NLRC4 Gene Variant Associates With Inflammation and Pulmonary Function in Human Immunodeficiency Virus and Tuberculosis

27 Sept 2019

Abstract excerpt

BACKGROUND: Inflammasomes mediate inflammation in adults living with both human immunodeficiency virus (HIV) and tuberculosis (TB), but the relevance of inflammasome gene polymorphisms in TB-associated pulmonary damage is unknown. We hypothesized that functional single-nucleotide polymorphisms (SNPs) in inflammasome pathway genes modify systemic and pulmonary inflammation, contributing to respiratory impairment...

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Share to Inflammasome and immune disorders
Share to Pneumocystis jirovecii pneumonia detection and treatment
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PMID: 31751447
DOI: 10.1093/cid/ciz898

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