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Article

Genetically downregulated interleukin-6 signaling is associated with a favorable cardiometabolic profile: a phenome-wide association study

2020-11-03

Abstract excerpt

<h4>Background</h4> Interleukin-6 (IL6) signaling is a key inflammatory pathway widely implicated in the pathogenesis of multiple diseases including autoimmune, vascular, and metabolic disorders. While IL6-receptor (IL6R) inhibitors are already in use for the treatment of autoimmune diseases, their repurposing potential and safety profile is still debated. <h4>Methods</h4> We used 7 genetic variants at the IL6R lo...

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Literature Corpus work
5eaddf9e-8702-5d62-8500-0085032d07f1
DOI
10.1101/2020.10.28.20220822
Open publication

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Genetically downregulated interleukin-6 signaling is associated with a favorable cardiometabolic profile: a phenome-wide association studyDOI 10.1101/2020.10.28.20220822
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