Article
Single nucleotide polymorphisms in toll-like receptor 6 are associated with altered lipopeptide- and mycobacteria-induced interleukin-6 secretion.
Genes and immunity - 1 Oct 2010
Shey M S, Randhawa A K, Bowmaker M, Smith E, Scriba T J, de Kock M, Mahomed H, Hussey G, Hawn T R, Hanekom W A
Abstract excerpt
Toll-like receptors (TLRs) are critical mediators of the immune response to pathogens. The influence of human TLR6 polymorphisms on susceptibility to infection is only partially understood. Most microbes contain lipopeptides recognized by TLR2/1 or TLR2/6 heterodimers. Our aim was to determine whether single nucleotide polymorphisms in TLR6 are associated with altered immune responses to lipopeptides and whole...
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