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Article

Mycobacterium tuberculosis, macrophages, and the innate immune response: does common variation matter?

Immunological reviews - 1 Oct 2007

Berrington William R, Hawn Thomas R

Abstract excerpt

Despite the discovery of the tuberculosis (TB) bacillus over 100 years ago and the availability of effective drugs for over 50 years, there remain a number of formidable challenges for controlling Mycobacterium tuberculosis (MTb). Understanding the genetic and immunologic factors that influence human susceptibility could lead to novel insights for vaccine development as well as diagnostic advances to target...

Topics

Animals
Cytokines
Genetic Predisposition to Disease
Humans
Immunity, Innate
Macrophages
Mycobacterium tuberculosis
Risk Factors
Toll-Like Receptors
Tuberculosis

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Identifiers

PMID: 17850489
DOI: 10.1111/j.1600-065X.2007.00545.x
PMCID: PMC2859969

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