Article
Association of IL-4 rs2243250 polymorphism with susceptibility to tuberculosis: A meta-analysis involving 6794 subjects.
Microbial pathogenesis - 1 Sept 2021
Liu Qianqian, Li Wenzhang, Chen Yunfeng
Abstract excerpt
BACKGROUND: Interleukin-4 (lL-4) is a critical negative cytokine in tuberculosis (TB) immune process, acting through modulating macrophages activation and Th1/Th2 balance. rs2243250 has been demonstrated to be associated with enhanced promoter strength in IL-4 expression. We performed a meta-analysis to assess the association between IL-4 rs2243250 polymorphism and TB risk. METHODS: We identified relevant studies...
Topics
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- Interleukin-4
- Polymorphism, Genetic
- Polymorphism, Single Nucleotide