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Article

Altered IL-6 signalling and risk of tuberculosis: a multi-ancestry mendelian randomisation study

21 Nov 2024

Abstract excerpt

BACKGROUND: The role of IL-6 responses in human tuberculosis risk is unknown. IL-6 signalling inhibitors, such as tocilizumab, are thought to increase the risk of progression to tuberculosis, and screening for latent Mycobacterium tuberculosis infection before using these drugs is widely recommended. We used single nucleotide polymorphisms (SNPs) in and near the IL-6 receptor gene (IL6R), including the...

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PMID: 39579785
DOI: 10.1016/s2666-5247(24)00162-9

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