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Article

A functional single-nucleotide polymorphism in the promoter of the gene encoding interleukin 6 is associated with susceptibility to tuberculosis.

The Journal of infectious diseases - 1 Jun 2012

Zhang Guoliang, Zhou Boping, Wang Wenfei, Zhang Mingxia, Zhao Yahua, Wang Zheng, Yang Lin, Zhai Jingnan, Feng Carl G, Wang Junwen, Chen Xinchun

Abstract excerpt

BACKGROUND: Genetic variation influences susceptibility or resistance to tuberculosis. Interleukin 6 (IL-6) contributes to protection against tuberculosis in mice. However, its role in regulating susceptibility or resistance to tuberculosis in humans is unclear. METHODS: Genotyping of polymorphisms in IL-6 and IL-6R (CD126) genes was performed in 2 independent cohorts, an experimental population (495 cases and...

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Identifiers

PMID: 22457277
DOI: 10.1093/infdis/jis266
PMCID: PMC3415858

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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