Article

Splicing of ultraconserved poison exons controls mitotic fidelity and stem cell viability

2026-05-21

Abstract excerpt

SR proteins are essential splicing regulators whose expression is controlled in part through poison exons (PEs) — ultraconserved non-coding exons that trigger nonsense-mediated decay — yet the biological functions of these elements remain undefined. Here, we show that homozygous deletion of SRSF3-PE or TRA2 β -PE is selected against in mouse embryos and human induced pluripotent stem cells (iPSCs), and that con...

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Literature Corpus work: d73c178e-88df-541b-bde3-d709be3e471e
DOI: 10.64898/2026.05.19.726407

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