Article
Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition.
Nature genetics - 1 May 2021
Inoue Daichi, Polaski Jacob T, Taylor Justin, Castel Pau, Chen Sisi, Kobayashi Susumu, Hogg Simon J, Hayashi Yasutaka, Pineda Jose Mario Bello, El Marabti Ettaib, Erickson Caroline, Knorr Katherine, Fukumoto Miki, Yamazaki Hiromi, Tanaka Atsushi, Fukui Chie, Lu Sydney X, Durham Benjamin H, Liu Bo, Wang Eric, Mehta Sanjoy, Zakheim Daniel, Garippa Ralph, Penson Alex, Chew Guo-Liang, McCormick Frank, Bradley Robert K, Abdel-Wahab Omar
Abstract excerpt
Most eukaryotes harbor two distinct pre-mRNA splicing machineries: the major spliceosome, which removes >99% of introns, and the minor spliceosome, which removes rare, evolutionarily conserved introns. Although hypothesized to serve important regulatory functions, physiologic roles of the minor spliceosome are not well understood. For example, the minor spliceosome component ZRSR2 is subject to recurrent,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.