Article

ESRP1-Mediated Alternative Splicing During Oocyte Development is Required for Mouse Fertility

2020-07-16

Abstract excerpt

Alternative splicing (AS) contributes to gene diversification in cells, but the importance of AS during germline development remains largely undefined. Here, we interrupted pre-mRNA splicing events controlled by epithelial splicing regulatory protein 1 (ESRP1) and found that it induced female infertility in mice. Germline-specific knockout of Esrp1 perturbed spindle organization, chromosome alignment, and metapha...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d2ff9fa1-9ae1-52c1-b28d-74cab2e68680
DOI: 10.1101/2020.07.16.206425

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ESRP1-Mediated Alternative Splicing During Oocyte Development is Required for Mouse FertilityDOI 10.1101/2020.07.16.206425Read

Maternal factor PABPN1L is essential for maternal mRNA degradation during maternal-to-zygotic transitionSemantic proximity Read

A conserved germline-specific Dsn1 alternative splice isoform supports oocyte and embryo developmentSemantic proximity Read

Maternal PRDM10 activates essential genes for oocyte-to-embryo transitionSemantic proximity Read

Unraveling the mysteries of early embryonic arrest: genetic factors and molecular mechanisms.Semantic proximity Read

Mouse ZAR1-like (XM_359149) colocalizes with mRNA processing components and its dominant-negative mutant caused two-cell-stage embryonic arrest.Semantic proximity Read

Single oocyte full-length isoform sequencing unveils the impact of transposable elements on RNA diversity and stability during oocyte maturationSemantic proximity Read

UHRF1 is essential for proper cytoplasmic architecture and function of mouse oocytes and derived embryosSemantic proximity Read

Novel variants in MEI1 cause female infertility characterized by early embryonic arrest and implantation failure.Semantic proximity Read

MARF1 regulates essential oogenic processes in mice.Semantic proximity Read

Azoospermia phenotype and scRNA-seq reveal hnRNPK as a factor essential for male germ cell development in mice.Semantic proximity Read

Cell-fate transition and determination analysis of mouse male germ cells throughout developmentSemantic proximity Read

RGS12 as a Novel Maternal-Effect Gene Causes Arrest at the Pronuclear Stage of Human ZygoteSemantic proximity Read