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Article

Regulation of constitutive and alternative mRNA splicing across the human transcriptome by PRPF8 is determined by 5' splice site strength.

Genome biology - 21 Sept 2015

Wickramasinghe Vihandha O, Gonzàlez-Porta Mar, Perera David, Bartolozzi Arthur R, Sibley Christopher R, Hallegger Martina, Ule Jernej, Marioni John C, Venkitaraman Ashok R

Abstract excerpt

BACKGROUND: Sequential assembly of the human spliceosome on RNA transcripts regulates splicing across the human transcriptome. The core spliceosome component PRPF8 is essential for spliceosome assembly through its participation in ribonucleoprotein (RNP) complexes for splice-site recognition, branch-point formation and catalysis. PRPF8 deficiency is linked to human diseases like retinitis pigmentosa or myeloid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26392272
DOI: 10.1186/s13059-015-0749-3
PMCID: PMC4578845

Genes

PRPF8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of constitutive and alternative mRNA splicing across the human transcriptome by PRPF8 is determined by 5' splice site strength.PMID 26392272Read ↗

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