Article
The minor spliceosome offers a therapeutically viable target for the treatment of a broad spectrum of cancers
2021-12-11
Abstract excerpt
Minor splicing is a second splicing system required for the correct expression of ∼700 human minor intron-containing genes (MIGs). Many MIGs are expressed in vigorously proliferating cells and are frequently dysregulated in cancer including BRAF, ERK, JNK and p38 . Minor splicing is carried out by the minor spliceosome which comprises several unique components, including a 65kDa protein encoded by RNPC3 . We sh...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- a84b18ca-dfb7-595c-99e5-d8025ca2f168
- DOI
- 10.1101/2021.12.09.469623