Article

SRSF12 is a primate-specific splicing factor that induces a tissue-specific gene expression program

2025-07-27

Abstract excerpt

Alternative splicing expands proteomic diversity and is tightly regulated by splicing factors, including the serine/arginine-rich (SR) protein family. Here, we analyze the poorly characterized protein SRSF12. Although SRSF12 is conserved across vertebrates, it is poorly expressed in most mammals, and we find that SRSF12 knockout mice do not display overt physiological or transcriptomic alterations. In contrast, SR...

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Literature Corpus work: c7248044-5664-56f5-b1a8-c78741f2f734
DOI: 10.1101/2025.07.25.666902

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