Article

Multimodal screen reveals noise regulatory proteins

2024-07-21

Abstract excerpt

<h4>SUMMARY</h4> Gene-expression noise can influence cell-fate choices across pathology and physiology. However, a crucial question persists: do regulatory proteins or pathways exist that control noise independently of mean expression levels? Our integrative approach, combining single-cell RNA sequencing with proteomics and regulator enrichment analysis, reveals 32 putative noise regulators. SON, a nuclear speckl...

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Literature Corpus work: 46c9c034-ed61-53f1-8bc0-f2420c9ac17a
DOI: 10.1101/2024.07.17.603871

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