Article

The E3/E4 ubiquitin ligase UFD-2 mediates negative feedback on Raf protein stability

2022-04-15

Abstract excerpt

Signaling by the kinase cascade comprised of Raf, MEK, and ERK is critical for animal development; moreover, its inappropriate activation is commonly found in human malignancies. In a genetic screen for factors that control signaling by the Caenorhabditis elegans Raf ortholog LIN-45, we found that it is negatively regulated by the E3/E4 ubiquitin ligase UFD-2. Both UFD-2 and its partner, the ATP-dependent unfolda...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d739880e-0d5f-538f-b495-6479555d6537
DOI: 10.1101/2022.04.14.488377

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The E3/E4 ubiquitin ligase UFD-2 mediates negative feedback on Raf protein stabilityDOI 10.1101/2022.04.14.488377Read

The Raf/LIN-45 C-terminal distal tail segment negatively regulates signaling in <i>Caenorhabditis elegans</i>Semantic proximity Read

The candidate MAP kinase phosphorylation substrate DPL-1 (DP) promotes expression of the MAP kinase phosphatase LIP-1 in C. elegans germ cells.Semantic proximity Read

Caenorhabditis elegans lin-45 raf is essential for larval viability, fertility and the induction of vulval cell fates.Semantic proximity Read

The Ras-ERK MAPK regulatory network controls dedifferentiation in Caenorhabditis elegans germline.Semantic proximity Read

Pseudokinase HPO-11 inhibits nonsense-mediated decay to ensure genome stability in <i>C. elegans</i>Semantic proximity Read

A lin-45 raf enhancer screen identifies eor-1, eor-2 and unusual alleles of Ras pathway genes in Caenorhabditis elegans.Semantic proximity Read

Regulation of protein quality control by UBE4B and LSD1 through p53-mediated transcription.Semantic proximity Read

DAF-18/PTEN protects LIN-35/Rb from CLP-1/CAPN-mediated cleavage to promote starvation resistanceSemantic proximity Read

Impeded Nedd4-1-Mediated Ras Degradation Underlies Ras-Driven TumorigenesisSemantic proximity Read

Fibroblast growth factor signaling in Caenorhabditis elegans.Semantic proximity Read

ERK signaling licenses SKN-1A/NRF1 for proteasome production and proteasomal stress resistanceSemantic proximity Read

An activating mutation in sos-1 identifies its Dbl domain as a critical inhibitor of the epidermal growth factor receptor pathway during Caenorhabditis elegans vulval development.Semantic proximity Read