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Article

The Ras-ERK MAPK regulatory network controls dedifferentiation in Caenorhabditis elegans germline.

Biochimica et biophysica acta - 1 Oct 2012

Cha Dong Seok, Datla Udaya Sree, Hollis Sarah E, Kimble Judith, Lee Myon-Hee

Abstract excerpt

How a committed cell can be reverted to an undifferentiated state is a central question in stem cell biology. This process, called dedifferentiation, is likely to be important for replacing stem cells as they age or get damaged. Tremendous progress has been made in understanding this fundamental process, but its mechanisms are poorly understood. Here we demonstrate that the aberrant activation of Ras-ERK MAPK...

Topics

Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cell Dedifferentiation
Enzyme Activation
Extracellular Signal-Regulated MAP Kinases
Germ Cells
Humans
MAP Kinase Signaling System
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mitogen-Activated Protein Kinase 1

Models, Biological

Mutation

Neoplasms

Protein Transport

Ribosomal Protein S6 Kinases, 90-kDa

Spermatocytes

ras Proteins

Source

Identifiers

PMID: 22820175
DOI: 10.1016/j.bbamcr.2012.07.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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