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Article

Caenorhabditis elegans lin-45 raf is essential for larval viability, fertility and the induction of vulval cell fates.

Genetics - 1 Feb 2002

Hsu Virginia, Zobel Cheri L, Lambie Eric J, Schedl Tim, Kornfeld Kerry

Abstract excerpt

The protein kinase Raf is an important signaling protein. Raf activation is initiated by an interaction with GTP-bound Ras, and Raf functions in signal transmission by phosphorylating and activating a mitogen-activated protein (MAP) kinase kinase named MEK. We identified 13 mutations in the Caenorhabditis elegans lin-45 raf gene by screening for hermaphrodites with abnormal vulval formation or germline function....

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Identifiers

PMID: 11861555
DOI: 10.1093/genetics/160.2.481
PMCID: PMC1461998

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Caenorhabditis elegans lin-45 raf is essential for larval viability, fertility and the induction of vulval cell fates.PMID 11861555Read ↗

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