Article

The Raf/LIN-45 C-terminal distal tail segment negatively regulates signaling in <i>Caenorhabditis elegans</i>

2024-07-17

Abstract excerpt

Raf protein kinases act as Ras-GTP sensing components of the ERK signal transduction pathway in animal cells, influencing cell proliferation, differentiation, and survival. In humans, somatic and germline mutations in the genes BRAF and RAF1 are associated with malignancies and developmental disorders. Recent studies shed light on the structure of activated Raf, a heterotetramer consisting of Raf and 14-3-3 dime...

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Literature Corpus work: bcfb9263-b835-5032-b4b5-f8c54e1e52f2
DOI: 10.1101/2024.07.16.603803

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