Article
An activating mutation in sos-1 identifies its Dbl domain as a critical inhibitor of the epidermal growth factor receptor pathway during Caenorhabditis elegans vulval development.
Molecular and cellular biology - 1 May 2007
Modzelewska Katarzyna, Elgort Marc G, Huang Jingyu, Jongeward Gregg, Lauritzen Amara, Yoon Charles H, Sternberg Paul W, Moghal Nadeem
Abstract excerpt
Proper regulation of receptor tyrosine kinase (RTK)-Ras-mitogen-activated protein kinase (MAPK) signaling pathways is critical for normal development and the prevention of cancer. SOS is a dual-function guanine nucleotide exchange factor (GEF) that catalyzes exchange on Ras and Rac. Although the physiologic role of SOS and its CDC25 domain in RTK-mediated Ras activation is well established, the in vivo function...
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