Article

ERK signaling licenses SKN-1A/NRF1 for proteasome production and proteasomal stress resistance

2021-01-04

Abstract excerpt

The ubiquitin-proteasome system is vital for cell growth and homeostasis, but for most cancers proteasomal inhibition has not been effective as a therapy. Normal and cancer cells adapt to proteasomal stress through an evolutionarily conserved recovery response, in which the transcription factor NRF1 upregulates proteasome subunit genes. Starting with a C. elegans screen to identify regulators of the recovery resp...

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Literature Corpus work: 1e926a08-c1cd-53c9-8020-f15eaff7df10
DOI: 10.1101/2021.01.04.425272

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