Article

DAF-18/PTEN protects LIN-35/Rb from CLP-1/CAPN-mediated cleavage to promote starvation resistance

2025-02-21

Abstract excerpt

<h4>ABSTRACT</h4> Starvation resistance is a fundamental trait with profound influence on fitness and disease risk. DAF-18, the C. elegans ortholog of the tumor suppressor PTEN, promotes starvation resistance. PTEN is a dual phosphatase, and DAF-18 promotes starvation resistance as a lipid phosphatase by antagonizing insulin/IGF and PI3K signaling, activating the tumor suppressor DAF-16/FoxO. However, if or how...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 441935f1-44ce-5dff-b8f6-f7c7fe5b970d
DOI: 10.1101/2025.02.17.638677

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DAF-18/PTEN protects LIN-35/Rb from CLP-1/CAPN-mediated cleavage to promote starvation resistanceDOI 10.1101/2025.02.17.638677Read

Early life starvation and Hedgehog-related signaling activate innate immunity downstream of daf-18/PTEN and lin-35/Rb causing developmental abnormalities in adult C. elegansSemantic proximity Read

Genetic redundancy masks diverse functions of the tumor suppressor gene PTEN during C. elegans development.Semantic proximity Read

Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene.Semantic proximity Read

The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway.Semantic proximity Read

DAF-18/PTEN inhibits germline zygotic gene activation during primordial germ cell quiescenceSemantic proximity Read

Coordinated regulation of intestinal functions in C. elegans by LIN-35/Rb and SLR-2.Semantic proximity Read

Doxycyclin ameliorates a starvation-induced germline tumor in C. elegans daf-18/PTEN mutant background.Semantic proximity Read

Genetic analysis of DAF-18/PTEN missense mutants for the ability to maintain quiescence of the somatic gonad and germ line in Caenorhabditis elegans dauer larvae.Semantic proximity Read

The PP2A/4/6 subfamily of phosphoprotein phosphatases regulates DAF-16 during aging and confers resistance to environmental stress in postreproductive adult <i>C. elegans</i>Semantic proximity Read

Insulin activates the insulin receptor to downregulate the PTEN tumour suppressor.Semantic proximity Read

A network of genes antagonistic to the LIN-35 retinoblastoma protein of Caenorhabditis elegans.Semantic proximity Read

A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling.Semantic proximity Read