Article

Pseudokinase HPO-11 inhibits nonsense-mediated decay to ensure genome stability in <i>C. elegans</i>

2022-09-04

Abstract excerpt

DNA double-strand breaks (DSBs) are highly toxic DNA lesions that can induce mutations and chromosome rearrangement therefore causing genome instability (GIN). In response to DSBs, cells activate the DNA damage response by hierarchical assembly of signaling and repair mechanisms. This involves recruitment of the repair factors at DSB sites, local chromatin remodeling, cell cycle arrest and, eventually, DNA repair...

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Literature Corpus work: 9bb2da84-e3b5-5ff0-beb9-c701382ab15f
DOI: 10.1101/2022.09.04.506508

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