Polygenic Risk Scores and Extreme Coronary Artery Calcium Phenotypes (CAC=0 and CAC≥1000) in Adults ≥75 Years Old: The ARIC Study.

doi:10.1161/CIRCIMAGING.123.016377

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Article

Polygenic Risk Scores and Extreme Coronary Artery Calcium Phenotypes (CAC=0 and CAC≥1000) in Adults ≥75 Years Old: The ARIC Study.

Circulation. Cardiovascular imaging - 1 Nov 2024

Dzaye Omar, Razavi Alexander C, Dardari Zeina A, Wang Frances M, Honda Yasuyuki, Nasir Khurram, Coresh Josef, Howard-Claudio Candace M, Jin Jin, Yu Bing, de Vries Paul S, Wagenknecht Lynne, Folsom Aaron R, Blankstein Ron, Kelly Tanika N, Whelton Seamus P, Mortensen Martin Bødtker, Wang Ziqiao, Chatterjee Nilanjan, Matsushita Kunihiro, Blaha Michael J

Abstract excerpt

BACKGROUND: Coronary artery calcium (CAC) is heterogeneous in older age and is incompletely explained by traditional atherosclerotic cardiovascular disease risk factors. The extremes of subclinical atherosclerosis burden are strongly associated with either a low or high 10-year risk of incident atherosclerotic cardiovascular disease, respectively. However, the genetic underpinnings of differences in arterial...

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PMID: 39534973
DOI: 10.1161/CIRCIMAGING.123.016377
PMCID: PMC11576240

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