Article

Co-option of CENP-A for activity-induced neuronal plasticity

2026-07-21

Abstract excerpt

Neuronal activation drives activity-dependent gene expression that underlies experience-associated synaptic modifications, learning and memory. Here we show that the histone variant CENP-A, best known for specifying centromere identity, is dynamically regulated by synaptic activity at both the RNA and protein levels in postmitotic neurons. Neuronal activation increases a non-centromeric nuclear pool of CENP-A whil...

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Literature Corpus work: d708704f-5649-50e9-bc89-53db47479223
DOI: 10.64898/2026.07.16.738894

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