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Non-centromeric CENP-A epigenetically regulates epithelial-mesenchymal plasticity and heterogeneity in human cells

2025-09-10

Abstract excerpt

The centromeric histone variant CENP-A, highly expressed in aggressive cancers, can promote an epithelial-mesenchymal transition (EMT) whose underlying mechanisms remain to decipher. Here, we tracked both the temporal dynamics of EMT states and CENP-A localization over time using a reversible high CENP-A expression system in human cells. Cell populations presenting hybrid EMT states at start, when exposed to high...

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Literature Corpus work
2b3eb22b-3f30-53d5-b4d9-f9bdefca373c
DOI
10.1101/2025.09.09.672651
Open publication

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Non-centromeric CENP-A epigenetically regulates epithelial-mesenchymal plasticity and heterogeneity in human cellsDOI 10.1101/2025.09.09.672651
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