Article

CENP-A overexpression drives distinct cell fates depending on p53 status

2020-07-21

Abstract excerpt

Tumour evolution is driven by both genetic and epigenetic changes. CENP-A, the centromeric histone H3 variant, is an epigenetic mark that directly perturbs genetic stability and chromatin when overexpressed. Although CENP-A overexpression is a common feature of many cancers, how this impacts cell fate and response to therapy remains unclear. Here, we established a tunable system of inducible and reversible CENP-A...

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Literature Corpus work: 87cee3c6-136c-5202-bfbc-f868934642d0
DOI: 10.1101/2020.07.21.213496

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