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Article

Genome-wide identification and characterization of functional neuronal activity-dependent enhancers.

Nature neuroscience - 1 Oct 2014

Malik Athar N, Vierbuchen Thomas, Hemberg Martin, Rubin Alex A, Ling Emi, Couch Cameron H, Stroud Hume, Spiegel Ivo, Farh Kyle Kai-How, Harmin David A, Greenberg Michael E

Abstract excerpt

Experience-dependent gene transcription is required for nervous system development and function. However, the DNA regulatory elements that control this program of gene expression are not well defined. Here we characterize the enhancers that function across the genome to mediate activity-dependent transcription in mouse cortical neurons. We find that the subset of enhancers enriched for monomethylation of histone...

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Identifiers

PMID: 25195102
DOI: 10.1038/nn.3808
PMCID: PMC4297619

Genes

FOS
CREBBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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