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Maternal CENP-C restores centromere symmetry in mammalian zygotes to ensure proper chromosome segregation

2025-07-28

Abstract excerpt

<h4>Summary</h4> Across metazoan species, the centromere-specific histone variant CENP-A is essential for accurate chromosome segregation, yet its regulation at the parental-to-zygote transition in mammals is poorly understood. To address this, we developed a CENP-A-mScarlet knock-in mouse model, which revealed sex-specific dynamics: mature sperm retains 10% of the CENP-A levels present in MII-oocytes. However, i...

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Identifiers and source

Literature Corpus work
f0f4b97a-53d1-51f0-a0ff-4e5221202632
DOI
10.1101/2025.07.23.666394
Open publication

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Maternal CENP-C restores centromere symmetry in mammalian zygotes to ensure proper chromosome segregationDOI 10.1101/2025.07.23.666394
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