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CENP-A overexpression promotes distinct fates in human cells, depending on p53 status

26 Mar 2021

Abstract excerpt

Tumour evolution is driven by both genetic and epigenetic changes. CENP-A, the centromeric histone H3 variant, is an epigenetic mark that directly perturbs genetic stability and chromatin when overexpressed. Although CENP-A overexpression is a common feature of many cancers, how this impacts cell fate and response to therapy remains unclear. Here, we established a tunable system of inducible and reversible CENP-A...

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PMID: 33772115
DOI: 10.1038/s42003-021-01941-5

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