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Article

Three-dimensional folding dynamics of the Xenopus tropicalis genome.

Nature genetics - 1 Jul 2021

Niu Longjian, Shen Wei, Shi Zhaoying, Tan Yongjun, He Na, Wan Jing, Sun Jialei, Zhang Yuedong, Huang Yingzhang, Wang Wenjing, Fang Chao, Li Jiashuo, Zheng Piaopiao, Cheung Edwin, Chen Yonglong, Li Li, Hou Chunhui

Abstract excerpt

Animal interphase chromosomes are organized into topologically associating domains (TADs). How TADs are formed is not fully understood. Here, we combined high-throughput chromosome conformation capture and gene silencing to obtain insights into TAD dynamics in Xenopus tropicalis embryos. First, TAD establishment in X. tropicalis is similar to that in mice and flies and does not depend on zygotic genome...

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Identifiers

PMID: 34099928
DOI: 10.1038/s41588-021-00878-z
PMCID: PMC8270788

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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