Article

Genome-wide alterations of uracil distribution patterns in human DNA upon chemotherapeutic treatments

2020-03-05

Abstract excerpt

<h4>ABSTRACT</h4> Numerous anti-cancer drugs perturb thymidylate biosynthesis and lead to genomic uracil incorporation contributing to their antiproliferative effect. Still, it is not yet characterized if uracil incorporations have any positional preference. Here, we aimed to uncover genome-wide alterations in uracil pattern upon drug-treatment in human cancer cell-line HCT116. We developed a straightforward U-DN...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d6d69a43-829c-5714-be06-28cb796d5fe9
DOI: 10.1101/2020.03.04.976977

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-wide alterations of uracil distribution patterns in human DNA upon chemotherapeutic treatmentsDOI 10.1101/2020.03.04.976977Read

Effects of thymidylate synthase inhibitors differ in genomic uracilation and mutagenic potential.Semantic proximity Read

Uracil DNA glycosylase (UNG) loss enhances DNA double strand break formation in human cancer cells exposed to pemetrexedSemantic proximity Read

Biochemical engineering of 5hmdC-DNA using a Tet3 double-mutantSemantic proximity Read

High resolution mapping of modified DNA nucleobases using excision repair enzymes.Semantic proximity Read

Multiomics and machine learning-based analysis of pseudouridine modifications in pan-cancerSemantic proximity Read

Nucleotide excision repair hotspots and coldspots of UV-induced DNA damage in the human genomeSemantic proximity Read

5-Fluorouracil treatment induces characteristic T>G mutations in human cancerSemantic proximity Read

Single-nucleotide-resolution genomic maps of <i>O</i> <sup>6</sup> -methylguanine from the glioblastoma drug temozolomideSemantic proximity Read

DNA Glycosylases Define the Outcome of Endogenous Base Modifications.Semantic proximity Read

UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporationSemantic proximity Read

Thymine DNA Glycosylase Binds to R-Loops and Excises 5-Formyl and 5-Carboxyl Cytosine from DNA/RNA HybridsSemantic proximity Read

Identification of the elementary structural units of the DNA damage responseSemantic proximity Read