Article

Biochemical engineering of 5hmdC-DNA using a Tet3 double-mutant

2025-06-11

Abstract excerpt

<h4>ABSTRACT</h4> 5-Hydroxymethyl-2’-deoxycytidine (5hmdC) is an important epigenetic marker involved in gene regulation and DNA demethylation. It has potential use as a biomarker for cancer and other diseases due to its significant depletion in various cancers and disease models. This research aimed to develop a reliable and efficient method for generating 5hmdC-containing DNA, addressing limitations in existing...

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Literature Corpus work: 86ef3362-27b7-502a-add9-ae90f2968956
DOI: 10.1101/2025.06.11.658802

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