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Effects of thymidylate synthase inhibitors differ in genomic uracilation and mutagenic potential.

Life science alliance - 1 Apr 2026

Holub Eszter, Papp Gábor, Pálinkás Hajnalka Laura, Szajkó Milda Blanka, Izrael Richard, Róna Gergely, Vértessy Beáta G, Békési Angéla

Abstract excerpt

Genomic uracil and its respective repair play key roles in colorectal, gastric, and other solid tumor therapies targeting thymidylate biosynthesis. Previously, we established that treating HCT116 colon cancer cell lines with either raltitrexed (RTX) or 5-fluoro-2'-deoxyuridine (5FdUR), two potent inhibitors of thymidylate synthase, results in characteristic genomic uracil patterns. Here, we focus on drug-specific...

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Identifiers

PMID: 41651672
DOI: 10.26508/lsa.202503352
PMCID: PMC12881662

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