Article

5-Fluorouracil treatment induces characteristic T>G mutations in human cancer

2019-06-25

Abstract excerpt

5-Fluorouracil (5-FU) is a chemotherapeutic drug component that is commonly used for the treatment of solid cancers. It is proposed that 5-FU possesses anticancer properties via the interference with nucleotide synthesis and incorporation into DNA. As both mechanisms may have a mutational impact on both surviving tumor and healthy cells, we treated intestinal organoids with 5-FU followed by whole genome sequencing...

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Literature Corpus work: 517a534a-6bc1-5834-81ba-8e5dca096074
DOI: 10.1101/681262

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