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Single-nucleotide-resolution genomic maps of <i>O</i> <sup>6</sup> -methylguanine from the glioblastoma drug temozolomide

2023-12-13

Abstract excerpt

<h4>ABSTRACT</h4> Temozolomide kills cancer cells by forming O 6 -methylguanine ( O 6 -MeG), which leads to apoptosis due to mismatch-repair overload. However, O 6 -MeG repair by O 6 -methylguanine-DNA methyltransferase (MGMT) contributes to drug resistance. Characterizing genomic profiles of O 6 -MeG could elucidate how O 6 -MeG accumulation is influenced by repair, but there are no methods to map genomic...

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Literature Corpus work
9a0bd78c-48fb-510a-8e3c-215485d42eff
DOI
10.1101/2023.12.12.571283
Open publication

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