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Article

High resolution mapping of modified DNA nucleobases using excision repair enzymes.

Genome research - 1 Sept 2014

Bryan D Suzi, Ransom Monica, Adane Biniam, York Kerri, Hesselberth Jay R

Abstract excerpt

The incorporation and creation of modified nucleobases in DNA have profound effects on genome function. We describe methods for mapping positions and local content of modified DNA nucleobases in genomic DNA. We combined in vitro nucleobase excision with massively parallel DNA sequencing (Excision-seq) to determine the locations of modified nucleobases in genomic DNA. We applied the Excision-seq method to map...

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Share to DNA Methylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25015380
DOI: 10.1101/gr.174052.114
PMCID: PMC4158761

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