Article

Thymine DNA Glycosylase Binds to R-Loops and Excises 5-Formyl and 5-Carboxyl Cytosine from DNA/RNA Hybrids

2025-08-05

Abstract excerpt

<h4>ABSTRACT</h4> R-loops are three-stranded nucleic acid structures consisting of a DNA/RNA hybrid and a displaced single-stranded DNA. Once considered rare byproducts of transcription, R-loops are now recognized as important regulators of various nuclear processes. In particular, evidence indicates a role for R-loops in regulating DNA methylation dynamics. R-loops have been shown to promote active DNA demethyla...

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Literature Corpus work: 52a52a12-e117-51c3-bc40-9fac7f0bfa57
DOI: 10.1101/2025.08.05.668694

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