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A phenotypic brain organoid atlas and biobank for neurodevelopmental disorders.

Cell stem cell - 4 Dec 2025

Wang Lu, Nakamura Yuji, Li Junhao, Sievert David, Liu Yang, Nguyen Toan, Jetti Prudhvi Sai, Thai Ethan, Zhou Rachel Yibei, Weng Jiaming, Meave Naomi, Yadavilli Manya, Howarth Robyn, Camey Kevin, Banka Niyati, Owusu-Hammond Charlotte, Barrows Chelsea, Kingsmore Stephen F, Zaki Maha S, Mukamel Eran, Gleeson Joseph G

Abstract excerpt

Thousands of genes are associated with neurodevelopmental disorders (NDDs), yet mechanisms and targeted treatments remain elusive. To fill these gaps, we present a California Institute of Regenerative Medicine (CIRM)-initiated NDD biobank of 352 publicly available genetically diverse patient-derived induced pluripotent stem cells (iPSCs), along with clinical details, brain imaging, and genomic data, representing...

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PMID: 41187745
DOI: 10.1016/j.stem.2025.10.006
PMCID: PMC13003759

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