Article

Patient-derived Induced Pluripotent Stem Cells as a Model to Study Frontotemporal Dementia Pathologies

2024-12-17

Abstract excerpt

<h4>ABSTRACT</h4> The neurodegenerative disorder Frontotemporal Dementia (FTD) can be caused by a repeat expansion (GGGGCC; G4C2) in C9orf72. The function of wild-type C9orf72 and the mechanism by which the C9orf72-G4C2 mutation causes FTD, however, remain unresolved. Diverse disease models including human brain samples and differentiated neurons from patient-derived induced pluripotent stem cells (iPSCs) identif...

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Literature Corpus work: be5e6762-9a94-5a70-b308-a30fb05f883a
DOI: 10.1101/2024.12.11.628042

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