Article

Optimization and scaling of patient-derived brain organoids uncovers deep phenotypes of disease

2020-08-27

Abstract excerpt

Cerebral organoids provide unparalleled access to human brain development in vitro. However, variability induced by current culture methodologies precludes using organoids as robust disease models. To address this, we developed an automated Organoid Culture and Assay (ORCA) system to support longitudinal unbiased phenotyping of organoids at scale across multiple patient lines. We then characterized organoid variab...

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Literature Corpus work: 0f41bd7d-7f6c-5b0b-89f5-0d1b363c94ad
DOI: 10.1101/2020.08.26.251611

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